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KMID : 1134820160450060903
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Journal of the Korean Society of Food Science and Nutrition
2016 Volume.45 No. 6 p.903 ~ p.910
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Natural Substance MS-10 Improves Women's Health via Regulation of Estrogen Receptor
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Noh Yoo-Hun
Lee Ji-Won
Park Ji-Ae
Lee Sang-Hyung
Lee Jun-Young
Kim Sung-Su
Park Kwang-Kyun
Kim Tae-Jin
Myung Soon-Chul
Jeong Yoon-Hwa
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Abstract
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In this study, the expression level of estrogen receptor in an ovariectomized rat model was effectively enhanced by MS-10, Cirsium japonicum and Thymus vulgaris extract complex, in a reversible manner. MS-10 plays a positive role in enhancing estrogen activity at low concentrations, leading to improved women's health. In order to determine whether or not MS-10 improves menopausal symptoms clinically, a randomized, double-blinded, and placebo-controlled clinical study was carried out on 62 middle-aged women treated with 500 mg of MS-10 or placebo daily for 12 weeks. Clinical menopausal symptoms were evaluated by Kupperman's index (KI) detecting various menopausal symptoms, including hot flushes, parenthesis, insomnia, nervousness, melancholia, dizziness, fatigue, rheumatic pain, palpitations, formication, and headaches. Total KI score decreased significantly by about 18% upon ingestion of MS-10. Colpoxerosis, a main symptom of menopause, was significantly reduced by about 21% upon ingestion of MS-10 in contrast to placebo. In addition, reduction of insulin-like growth factor-1 with age was improved by over 10% upon ingestion of MS-10, whereas there were no significant difference with placebo. No side effects appeared after treatment with MS-10. Thus, MS-10 can be suggested as a plausible natural substance for improving women's health.
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KEYWORD
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MS-10, menopause, colpoxerosis, Kupperman's index, estrogen receptor
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